Endocrine Abstracts

Objective: The majority of circulating testosterone is bound to sex hormone-binding globulin (SHBG), but also to albumin and cortisol-binding globulin. The remaining part is free-circulating testosterone unattached to serum proteins, which represents the active form of the hormone. A common measurement of the free testosterone is the calculated free testosterone index (FTI)=100*(total testosterone/SHBG). Testosterone is the principal male sex hormone and is involved in the reg...

Context: Previous studies suggest that total testosterone levels influences lipid metabolism. It has not been investigated whether these levels are prospectively associated with an unfavourable lipid profile including increased risk of incident dyslipidemia.Design and setting: We used data of 1468 men aged 20–79 years, repeatedly examined in the population-based Study of Health in Pomerania. Serum total testosterone levels, measured by chemiluminesc...

Objective: Age- and gender-specific reference values for quality of life (QoL) measures are important to assess the impact of growth hormone deficiency (GHD). The objective of this study was to develop population-based data for the QoL-AGHDA instrument for Germany and to compare this data with corresponding Qol-AGHDA scores of the German KIMS cohort during growth hormone treatment, to investigate the association between the Qol-AGHDA score and the IGF-1 values in the German KI...

Background: Obesity is a major risk factor for the development of chronic diseases and a determinant of cardiovascular disease. Divergent associations between obesity and hormonal changes have been reported. The objective of the present study was to analyse the associations between different anthropometric measurements and serum hormone levels including insulin-like growth factor 1 (IGF-1), thyroid-stimulation hormone (TSH), prolactin, and testosterone.M...

Background, objective: Adipose tissue is known to secrete a multitude of bioactive adipokines and it seems that the majority of these adipokines is implicated in the pathogenesis of obesity and associated metabolic diseases. Existing research studies mostly concentrated on one or two adipokines and therefore, comparisons of the involvement of different adipokines in these disorders are difficult. Furthermore, associations of circulating adipokine levels with different fat comp...

Background: Prospective studies showed that low serum testosterone concentrations are associated with various cardiometabolic risk factors and mortality. But the causal nature of these associations is controversial.Methods: We studied 1882 men aged 20–79 years with serum testosterone concentrations and genotyping data from the longitudinal population-based Study of Health in Pomerania.Testosterone concentrations were cross-sec...

Aim: The aim of this analysis was to determine whether low serum testosterone (T) and dehydroepiandrosterone sulfate (DHEAS) levels predict the development of metabolic syndrome (MetS) in men.Methods: Data were obtained from the Study of Health in Pomerania (SHIP), a population-based prospective cohort of adults aged 20–79 at baseline. Analyses were conducted in 1004 men without baseline MetS, defined by National Cholesterol Education Program Adult ...

The functional state of the thyroid is usually determined by thyrotropin (TSH), whose serum levels depend on circulating thyroid hormone (TH) levels. This feedback mechanism is tightly controlled in the individual and contrasts broad reference range for TSH in the general population, leading to the concept of subclinical thyroid disease. We studied a model of experimental thyrotoxicosis in humans employing an untargeted metabolome and proteome approach. This allowed us to gain...

Introduction: To date, associations between sex hormones and sleep were mainly investigated in small and selected patient-based samples. Thus, we examined a comprehensive panel of mass spectrometry-measured sex hormones and various sleep characteristics in a population-based sample of healthy men and women from the general population.Methods: We used data from 204 men and 213 women of the cross-sectional Study of Health in Pomerania TREND, who underwent ...

Background: Numerous animal models have shown impressive beneficial metabolic effects of the putative thyroid hormone (TH)-derivative 3,5-diiodothyronine (3,5-T2), including the prevention of insulin resistance or the reversal of hepatic steatosis, in the absence of thyrotoxic side effects. In contrast, the endogenous fate of 3,5-T2 in humans is still unclear. Comprehensive molecular profiling holds promise to gain deeper insights in metabolic alterations associated with serum...